Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)

Mouse

synthetic peptide from human Akt1 containing phospho-serine473

Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 38 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2.WARNING This product is not for human or veterinary use.

For immunochemical analysis of Akt1 (Phospho-Ser473)

IgG2κ

14A282

Antibodies/Primary Antibodies/Monoclonal Antibodies

Immunoprecipitation,Western Blot

(+) Human Akt1 (+) Mouse Akt1

≥ 1 year