Akt1 (Phospho-Ser473) Monoclonal Antibody (Clone 104A282)

Mouse

synthetic peptide from human Akt1 containing phospho-serine473

For immunochemical analysis of Akt1 (Phospho-Ser473)

Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer, as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt/PKB kinase activity. Akt/PKB phosphorylation is critical for its activity. The major phosphorylation sites required for Akt activation have been identified as threoinine 308 and serine 473. Serine473 is phosphorylated by MAPKAP kinase 2.

IgG2κ

104A282

IP and WB

(+) Human Akt1 (+) Mouse Akt1

≥ 1 year