AKT2 (v-akt murine thymoma viral oncogene homolog 2, PKBB, PKBBETA, PKB beta, PRKBB, Protein kinase Akt-2, Protein kinase B beta, RAC-BETA, RAC-beta serine/threonine-protein kinase, RAC-PK-beta)

Human

Mouse

Purified recombinant fragment of human AKT2 expressed in E. coli.

Suitable for use in ELISA, Western Blot and Immunofluorescence. Other applications not tested.

Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

IgG2b

10F597

Monoclonal

Ascites

Supplied as a liquid, 0.03% sodium azide.

E IF WB

ELISA: 1:10,000 Western Blot: 1:500-1:2000 Immunofluorescence: 1:200-1:1000 Optimal dilutions to be determined by the researcher.

Mouse

Hu Mk Rt

Recognizes human AKT2 at 60kD. Species Crossreactivity: rat, monkey.

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