Akti-1/2 (10 mg)

10196499

Potent and selective dual Akt1 and 2 inhibitor

551.64

1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

Potent and selective dual Akt1 and 2 inhibitor (IC₅₀ values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Active in vivo.

≥98% (HPLC)

Soluble to 20 mM in DMSO with gentle warming

Akt Inhibitor VIII

O=C1NC2=C(C=CC=C2)N1C(CC3)CCN3CC(C=C4)=CC=C4C5=NC6=CC(N=CN7)=C7C=C6N=C5C8=CC=CC=C8

C₃₄H₂₉N₇O

612847-09-3