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Alexa Fluor® 555 Anti-Bcl-XL antibody [E18]
品牌： Abcam
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对比
咨询纯度：
Protein A purified
反应种属：
Human, Mouse, Rat
产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed : 17418785).. Isoform Bcl-X(S) promotes apoptosis.
宿主
Rabbit
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
简单描述
Alexa Fluor® 555荧光兔单克隆抗体[E18] to Bcl-XL
商品描述
Rabbit Recombinant Monoclonal Bcl-XL antibody - conjugated to Alexa Fluor® 555. Suitable for IHC-P, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples.
同种型
IgG
克隆号
E18
克隆类别
单克隆
纯度
Protein A purified
浓度
0.5 mg/mL 本产品的浓度可能与批次相关
形式
Liquid
研究领域
细胞生物学
应用
实验应用
Flow Cyt (Intra), IHC-P
反应种属
Human, Mouse, Rat
目标/特异性
This antibody should recognize Bcl-XL, Bcl-xS and Bcl-x(beta) as the immunogen sequence is common to them. The antibody does not cross-react with other Bcl-2 family members.
背景
别名
BCL2L, BCLX, BCL2L1, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X
研究领域
Cell Biology Apoptosis Intracellular Bcl2 Family Signal Transduction Metabolism Mitochondrial Cancer Invasion/microenvironment Apoptosis Bcl 2 family Cancer Oncoproteins/suppressors Oncoproteins Cell survival & death Cancer Tumor biomarkers Oncoproteins Cancer Cancer Metabolism Response to hypoxia Metabolism Pathways and Processes Mitochondrial Metabolism Mitochondrial markers Metabolism Pathways and Processes Metabolism processes Hypoxia Metabolism Pathways and Processes Metabolism processes Apoptosis Cancer Cell Death Apoptosis Apoptosis Markers Bcl 2 family Cancer Cell Death Apoptosis Metabolism
制备和贮存
存储溶液
pH: 7.4Preservative: 0.02% Sodium azideConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Store In the Dark.
数据库链接
UniProt ID
Q07817&&Q07817&&Q64373&&P53563
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