Alexa Fluor® 647 Anti-Sialoadhesin/CD169 antibody [SP216]

Purified from TCS by protein A/G.

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed : 12940982, PubMed : 33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs) (PubMed : 28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed : 28129379, PubMed : 34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed : 12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed : 26358190).. (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane.

Rabbit

Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

Alexa Fluor® 647荧光兔单克隆抗体[SP216] to Sialoadhesin/CD169

IgG

SP216

单克隆

Protein A/G purified

0.5 mg/mL 本产品的浓度可能与批次相关

Liquid

免疫学和肿瘤学

Flow Cyt (Intra), IHC-P

Human

CD169, SN, SIGLEC1, Sialoadhesin, Sialic acid-binding Ig-like lectin 1, Siglec-1

pH: 7.4Preservative: 0.02% Sodium azideConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS

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