Alexa Fluor® 647 Anti-CD33 antibody[EPR23052-5]

Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed : 10611343, PubMed : 11320212, PubMed : 15597323). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed : 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed : 10887109, PubMed : 28325905). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed : 10206955, PubMed : 10556798, PubMed : 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed : 10206955, PubMed : 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed : 15597323).

Rabbit

Recombinant fragment within Human CD33 aa 1-300. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.Database link: P20138 Run BLAST with Run BLAST with

Alexa Fluor® 647荧光兔单克隆抗体[EPR23052-5] to CD33

IgG

EPR23052-5

单克隆

Protein A purified

0.5 mg/mL 本产品的浓度可能与批次相关

Liquid

免疫学和肿瘤学

Flow Cyt

Human

CD33, SIGLEC3, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, gp67, Siglec-3

pH: 7.4Preservative: 0.02% Sodium azideConstituents: 30% Glycerol (glycerin, glycerine), 1% BSA, 68% PBS

P20138&&P20138&&P20138