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hALK/CD246 MAb (Cl 3 (25 ug)

hALK/CD246 MAb (Cl 3 (25 ug)

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品牌: R&D Systems
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来源宿主:
Mouse IgG2a
实验应用:
Western Blot(1 µg/mL)
产品介绍
产品介绍
产品信息
荧光素标记
纯化方式
Protein A or G purified from hybridoma culture supernatant
抗原名称
ALK tyrosine kinase receptor, ALK, anaplastic lymphoma kinase (Ki-1), Anaplastic lymphoma kinase, an
宿主
Mouse IgG2a
免疫原
Mouse myeloma cell line NS0-derived recombinant human ALK/CD246
Val19-Ser1038
Accession # Q9UM73
克隆号
383625

Human ALK/CD246 Antibody Summary

Species Reactivity
Human
Specificity
Detects human ALK/CD246 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG2A Clone # 383625
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ALK/CD246
Val19-Ser1038
Accession # Q9UM73
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human ALK/CD246

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

组成成分
IGG-免疫球蛋白G型抗体
应用
实验应用
Western Blot(1 µg/mL)
背景
别名
ALK tyrosine kinase receptor,ALK,anaplastic lymphoma kinase (Ki-1),Anaplastic lymphoma kinase,anaplastic lymphoma receptor tyrosine kinase,CD246 antigen,CD246,EC 2.7.10.1,Ki-1,NBLST3,Tcrz,Anaplastic Lymphoma Kinase
背景

Background: ALK/CD246

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDLR class A domain, two MAM domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

Long Name
Anaplastic Lymphoma Kinase
Entrez Gene IDs
238 (Human); 11682 (Mouse); 266802 (Rat)
Alternate Names
ALK tyrosine kinase receptor; ALK; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246 antigen; CD246; EC 2.7.10.1; Ki-1; NBLST3; Tcrz
制备和贮存
溶解方法
Reconstitute at 0.5 mg/mL in sterile PBS.
保存方式

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
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货号:
MAB4210-SP
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