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hALK/CD246 MAb (Cl 3 (25 ug)

品牌： R&D Systems

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产品介绍

产品信息

荧光素标记

Unconjugated

纯化方式

Protein A or G purified from hybridoma culture supernatant

抗原名称

ALK tyrosine kinase receptor， ALK， anaplastic lymphoma kinase (Ki-1)， Anaplastic lymphoma kinase， an

宿主

Mouse IgG2a

免疫原

Mouse myeloma cell line NS0-derived recombinant human ALK/CD246
Val19-Ser1038
Accession # Q9UM73

克隆号

383625

Human ALK/CD246 Antibody Summary

Species Reactivity

Human

Specificity

Detects human ALK/CD246 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG_2A Clone # 383625

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ALK/CD246
Val19-Ser1038
Accession # Q9UM73

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human ALK/CD246

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

组成成分

IGG-免疫球蛋白G型抗体

应用

实验应用

Western Blot(1 µg/mL)

背景

别名

ALK tyrosine kinase receptor,ALK,anaplastic lymphoma kinase (Ki-1),Anaplastic lymphoma kinase,anaplastic lymphoma receptor tyrosine kinase,CD246 antigen,CD246,EC 2.7.10.1,Ki-1,NBLST3,Tcrz,Anaplastic Lymphoma Kinase

背景

Background: ALK/CD246

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDLR class A domain, two MAM domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

Long Name

Anaplastic Lymphoma Kinase

Entrez Gene IDs

238 (Human); 11682 (Mouse); 266802 (Rat)

Alternate Names

ALK tyrosine kinase receptor; ALK; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246 antigen; CD246; EC 2.7.10.1; Ki-1; NBLST3; Tcrz

研究领域

Related Research Areas

制备和贮存

溶解方法

Reconstitute at 0.5 mg/mL in sterile PBS.

保存方式

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

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货号：

MAB4210-SP

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询价

25ug

100ug

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