4-(7-丁基-5H-吡咯并[2,3-b]吡嗪-6-基)苯酚

Aloisine A is a cell permeable, potent, selective, reversible, and ATP-competitive inhibitor of Cdc2 (CDK1)/cyclin B (IC₅₀ = 150nM), Cdk2/cyclin A (IC₅₀ = 120nM), Cdk2/cyclin E (IC₅₀ = 400nM), Cdk5/p25 (IC₅₀ = 200nM), Cdk5/p35 (IC₅₀ = 160nM), and GSK-3α (IC₅₀ = 500nM). Aloisine A also inhibits GSK-3β (IC₅₀ = 650nM) and JNK (c-Jun N-terminal kinase) (IC₅₀~3-10μM). Aloisine A is a poor inhibitor of CK1, CK2, Cdk4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC₅₀ ≥ 100μM). Aloisine A blocks the cell cycle in both G1 and G2 phase. Aloisine A is an activator of CFTR.

≥95%