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ALPHA-SYNUCLEIN ANTIBODY
ALPHA-SYNUCLEIN ANTIBODY
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ALPHA-SYNUCLEIN ANTIBODY

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品牌： Thermo
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建议稀释比
已发表文章

免疫印迹 (WB)

1:400
-

免疫组化（冰冻） (IHC (F))

1:300
-
产品规格

种属反应

Mouse,Rat

宿主/亚型

Guinea pig / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)KDQMGKGEEGYPQE, corresponding to amino acid residues 97-110 of rat alpha-synuclein, Intracellular, C-terminus
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Alpha synuclein; Alpha-synuclein; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor

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基因别名: alphaSYN; NACP; Snca; Syn

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UniProt ID:(Rat) P37377, (Mouse) O55042

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Entrez Gene ID:(Rat) 29219, (Mouse) 20617

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功能
magnesium ion binding fatty acid binding copper ion binding calcium ion binding protein binding phospholipid binding microtubule binding ferrous iron binding zinc ion binding oxidoreductase activity kinesin binding enzyme binding protein domain specific binding Hsp70 protein binding histone binding identical protein binding alpha-tubulin binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process phospholipase binding dynein binding protein N-terminus binding tau protein binding beta-tubulin binding arachidonic acid binding phosphoprotein binding phospholipase D inhibitor activity metal ion binding membrane trafficking regulatory protein
参与通路
microglial cell activation positive regulation of receptor recycling negative regulation of protein phosphorylation positive regulation of neurotransmitter secretion synaptic transmission, dopaminergic fatty acid metabolic process neutral lipid metabolic process phospholipid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process mitochondrial membrane organization chemical synaptic transmission aging adult locomotory behavior response to iron(II) ion regulation of phospholipase activity negative regulation of platelet-derived growth factor receptor signaling pathway regulation of glutamate secretion regulation of dopamine secretion negative regulation of microtubule polymerization receptor internalization protein destabilization response to magnesium ion negative regulation of transporter activity response to lipopolysaccharide negative regulation of monooxygenase activity positive regulation of peptidyl-serine phosphorylation response to interferon-gamma cellular response to oxidative stress negative regulation of histone acetylation regulation of locomotion response to cocaine dopamine biosynthetic process dopamine metabolic process response to drug mitochondrial ATP synthesis coupled electron transport regulation of macrophage activation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of endocytosis negative regulation of exocytosis negative regulation of dopamine metabolic process regulation of neurotransmitter secretion behavioral response to cocaine regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport positive regulation of synaptic transmission synapse organization regulation of acyl-CoA biosynthetic process positive regulation of release of sequestered calcium ion into cytosol negative regulation of dopamine uptake involved in synaptic transmission negative regulation of serotonin uptake negative regulation of norepinephrine uptake calcium ion homeostasis oxidation-reduction process excitatory postsynaptic potential long-term synaptic potentiation positive regulation of inositol phosphate biosynthetic process membrane organization negative regulation of thrombin receptor signaling pathway response to interleukin-1 cellular response to copper ion positive regulation of protein serine/threonine kinase activity regulation of neuron death positive regulation of glutathione peroxidase activity positive regulation of hydrogen peroxide catabolic process regulation of reactive oxygen species metabolic process

参考图片

Expression of Alpha-Synuclein in rat hippocampus. Expression of Alpha-Synuclein in rat hippocampus. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Guinea Pig Anti-Alpha-Synuclein Antibody (#APZ-035-GP), (1:300), followed by goat Anti-guinea pig-AlexaFluor-594. A. Alpha-Synuclein immunoreactivity (red) appears in the mossy fiber terminal region (MFT). B. Pre-incubation of the Antibody with Alpha-Synuclein Blocking Peptide (BLP-PZ035), suppressed staining. Cell nuclei are stained with DAPI (blue). G = granule layer.

Western blot analysis of rat brain lysate (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4): - 1-2. Guinea Pig Anti-Alpha-Synuclein Antibody (#APZ-035-GP), (1:400). 3-4. Guinea Pig Anti-Alpha-Synuclein Antibody , preincubated with Alpha-Synuclein Blocking Peptide (BLP-PZ035).

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货号：
APZ-035-GP200UL
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200UL
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