Angiomotin (E3E7X) Rabbit mAb

Angiomotin (AMOT) is a widely expressed cell junction protein initially identified through its ability to bind angiostatin. Alternative splicing results in two isoforms of angiomotin, the full-length p130 and the amino-terminally truncated p80. These isoforms, along with angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2), comprise the Motin protein family. Angiomotin is important in endothelial cell polarity, migration, and blood vessel formation during development, as well as in signaling through small GTPases and the Hippo/YAP pathway (reviewed in 1). Research studies have shown that angiomotin expression regulates migration and proliferation of breast cancer cells (2,3). 1.Moleirinho, S. et al. (2014) FEBS Lett 588, 2693-703. 2.Zhang, H. and Fan, Q. (2015) Oncol Rep 34, 2163-70. 3.Lv, M. et al. (2015) Oncol Rep 33, 1938-46.