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Anti-ASIC2a Antibody
品牌： Alomone
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咨询纯度：
Affinity purified on immobilized antigen.
反应种属：
H, M, R
产品介绍
产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
Rabbit
简单描述
A Rabbit Polyclonal Antibody to ASIC2a Channel
商品描述
Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to ASIC2a Channel
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
组成成分
酸感应离子通道2抗体、0.05%叠氮化钠溶液
基因
ASIC2
应用
实验应用
ICC, IF, IHC, IP, WB
反应种属
H, M, R
目标/特异性
The antibody is specific for ASIC2a and will not recognize ASIC2b.
背景
别名
ACCN1, Acid-sensing ion channel 2, Brain sodium channel 1, BNaC1, BNC1, Amiloride-sensitive cation channel neuronal 1, Mammalian degenerin homolog, MDEG
背景
ASIC2a is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial Na+ channels (DEG/ENaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini.
There are two recognized splice variants of the ASIC2 gene that differ on their N-termini, ASIC2a and ASIC2b that have different tissue distributions and functions. ASIC2a is highly expressed in the central nervous system (CNS) and is less expressed in the peripheral nervous system (PNS) while ASIC2b is prominently expressed in the latter.
The functional channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits. The ASIC2b splice variant does not appear to be functional when expressed alone but it can modify the properties of ASIC2a and ASIC3 when co-expressed.
The ASIC2 protein has been proposed to be involved in mechanosensation and sensory transduction.
There are two recognized splice variants of the ASIC2 gene that differ on their N-termini, ASIC2a and ASIC2b that have different tissue distributions and functions. ASIC2a is highly expressed in the central nervous system (CNS) and is less expressed in the peripheral nervous system (PNS) while ASIC2b is prominently expressed in the latter.
The functional channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits. The ASIC2b splice variant does not appear to be functional when expressed alone but it can modify the properties of ASIC2a and ASIC3 when co-expressed.
The ASIC2 protein has been proposed to be involved in mechanosensation and sensory transduction.
制备和贮存
溶解方法
25 μl, 50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
40
UniProt ID
Q16515
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