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Anti-CaV1.2a (CACNA1C) Antibody
品牌： Alomone
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咨询纯度：
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then anti-Cav1.2a antibody was affinity purified on immobilized CardN1-46(S44A).
反应种属：
H, M, R
产品介绍
产品介绍
产品信息
纯化方式
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and then the IgG fraction was purified on immobilized antigen.
宿主
兔
免疫原
GST fusion protein with the sequence MLRALVQPATPAYQPLPSHLSAETESTCKGTVVHEAQLNHFYISPG, corresponding to amino acid residues 1-46 of rabbit CaV1.2a, with serine 44 replaced with alanine (Accession P15381). Intracellular, N-terminus.
简单描述
A Rabbit Polyclonal Antibody to CaV1.2a (CACNA1C) Channel
商品描述
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rabbit CaV1.2a channel. Anti-CaV1.2a (CACNA1C) Antibody (#ACC-013) can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize CaV1.2a from mouse, rat and human samples.
同种型
Rabbit IgG.
纯度
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then anti-Cav1.2a antibody was affinity purified on immobilized CardN1-46(S44A).
形式
Lyophilized
组成成分
电压依赖性L型钙通道蛋白多克隆抗体，0.05%叠氮化钠溶液，磷酸盐缓冲液
基因
CACNA1C
应用
实验应用
ICC, IF, IHC, IP, WB
反应种属
H, M, R
背景
别名
Cardiac type α1C, Voltage-dependent L-type calcium channel subunit alpha-1C.
背景
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells.
Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700).
All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), CaV1.3 channels are found in heart, brain and pancreas and CaV1.2 channels are ubiquitously expressed.
There are two splice variants to the Cav1.2 channel designated Cav1.2a and Cav1.2b. The expression of the Cav1.2b variant is restricted to smooth muscle while Cav1.2a specifically expressed in cardiac muscle.
Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700).
All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), CaV1.3 channels are found in heart, brain and pancreas and CaV1.2 channels are ubiquitously expressed.
There are two splice variants to the Cav1.2 channel designated Cav1.2a and Cav1.2b. The expression of the Cav1.2b variant is restricted to smooth muscle while Cav1.2a specifically expressed in cardiac muscle.
制备和贮存
溶解方法
25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
100101555
UniProt ID
P15381
研究资源识别码
AB_2039773.
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