Anti-CD47 antibody (DM49), Rabbit mAb

Purified from cell culture supernatant by affinity chromatography

Leukocyte surface antigen CD47

Recombinant human CD47 (Gln19-Glu141, Val198-Ala207, Ser257-Gly268) produced by using human HEK293 cells

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

DM49

Liquid. 50% Glycerol; PBS, pH7.4; 0.1% BSA; 0.1% Procline 300

Monoclonal

ELISA (EIA), Flow Cytometry (FC/FACS)

Human

CD47; MER6; IAP; OA3

961

Q08722 [Other Products]