Anti-Hu CD66e Purified

Purified

Purified by protein-A affinity chromatography.

CD66e

Human carcinoembryonic antigen (CEA; CEACAM5)

The CD66e (CEA; 180-200 kDa) is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion. Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas - potential target of tumor imaging and drug targeting.

Mouse IgG1

CB30

1 mg/ml

IP, FC (QC tested), IHC-F, IHC-P Immunohistochemistry (paraffin sections): Staining technique: standard ABC technique (DAB+), recommended dilution: 10 μg/ml (1:100), positive tissue: adenocarcinoma of colon, pretreatment: 0,1% pepsin in 0,1 M HCl for 30 min at room temperature.

Human

The mouse monoclonal antibody CB30 recognizes CD66e (CEA; 180-200 kDa), an extracellular cell surface-bound carcinoembryonic antigen mainly expressed on epithelial cells.

CEACAM5, CEA

1048

P06731