Anti-IL-17RA antibody (DM125), Rabbit mAb

Purified from cell culture supernatant by affinity chromatography

interleukin-17 receptor A

Recombinant human IL-17RA (Leu33-Trp320) produced by using human HEK293 cells

Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.

DM125

Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization. 0.1% Procline 300

Monoclonal

Flow Cytometry (FC/FACS)

Human

CD217; CDw217; IL-17RA; IL17R; CANDF5; hIL-17R

23765

Q96F46 [Other Products]