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Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody
品牌： Alomone
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咨询纯度：
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then the antibody was affinity purified on immobilized KCa1.1-GST.
反应种属：
M, R
产品介绍
产品介绍
产品信息
纯化方式
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and then the IgG fraction was purified on immobilized antigen.
宿主
兔
免疫原
GST fusion protein with the sequenceSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVEDEC, corresponding to residues 1097-1196 of mouse KCNMA1 variant 2 (Accession Q08460-2). Intracellular, C-terminus.
简单描述
A Rabbit Polyclonal Antibody to KCNMA1 (KCa1.1) Channel
商品描述
Anti-KCNMA1 (KCa1.1) (1097-1196) Antibody (#APC-021) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot, immunoprecipitation, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize KCNMA1 from human, mouse, and rat samples.
同种型
Rabbit IgG.
纯度
The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then the antibody was affinity purified on immobilized KCa1.1-GST.
形式
Lyophilized
组成成分
大电导钙激活钾通道蛋白多克隆抗体，0.05%叠氮化钠溶液，磷酸盐缓冲液
基因
KCNMA1
应用
实验应用
ICC, IF, IHC, IP, WB
反应种属
M, R
预测反应种属
H
背景
别名
Large conductance calcium-activated potassium channel subfamily M subunit alpha-1, BKCa alpha, Maxi K+, Slo1
背景
The KCa1.1 channel (also known as BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recorded electrophysiologically and hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization. In addition, the KCa1.1 channel structurally differs from the other Ca2+-dependent K+ channels. While the latter group has a topology that resembles that of the voltage-dependent K+ channels, the KCa1.1 channel has an extracellular N-terminus domain as well as an additional transmembrane domain.
KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to connect between intracellular Ca2+ signaling pathways and membrane excitability.
Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.
KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to connect between intracellular Ca2+ signaling pathways and membrane excitability.
Indeed, KCa1.1 channels play a crucial role in smooth muscle contractility, neuronal spike shaping and neurotransmitter release.
制备和贮存
溶解方法
25 µl, 50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
16531
UniProt ID
Q08460-2
研究资源识别码
AB_2313725.
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