Anti-KCNN1 (KCa2.1, SK1) Antibody

K_Ca2.1 is a member of the Ca²⁺-activated K⁺ channels family with small conductance that includes K_Ca2.2 (SK2) and K_Ca2.3 (SK3). The channel is voltage insensitive and is activated by intracellular Ca²⁺ in the submicromolar range. It has a similar topology to that of voltage-dependent K⁺ channels (K_V channels), that is six transmembrane domains and intracellular N- and C-termini. 

K_Ca2.1 channel expression is roughly confined to neuronal tissue, although there are some indications that it may be present in non-neuronal tissues as well.  

The sensitivity of K_Ca2.1 to the bee venom toxin Apamin (#STA-200) is a matter of some controversy. Expression of the human K_Ca2.1 in mammalian cell lines showed that most cells produce channels that can be blocked by Apamin. However, expression of K_Ca2.1 in Xenopus oocytes produced channels that were mostly insensitive to apamin. Interestingly, the rat K_Ca2.1 is unable to form functional channels when expressed alone in either cell lines or oocytes.