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Anti-Kir4.1 (KCNJ10) Antibody
品牌： Alomone
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咨询纯度：
Affinity purified on immobilized antigen.
反应种属：
H, M, R
产品介绍
产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
兔
简单描述
A Rabbit Polyclonal Antibody to Kir4.1 (KCNJ10) Channel
商品描述
Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Kir4.1 Channel
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
基因
KCNJ10
应用
实验应用
ICC, IF, IHC, IP, WB
反应种属
H, M, R
背景
别名
ATP-sensitive inward rectifier potassium channel 10, KAB-2, BIR10, BIRK1, Kir1.2, Potassium channel inwardly rectifying subfamily J member 10
背景
Kir4.1 is a member of the inward rectifying K+ channel family. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels.
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heteromers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.
Kir4.1 is a member of the Kir4 subfamily that includes one other member: Kir4.2. Kir4.1 can co-assemble with Kir4.2 but also with other Kir channels such as Kir2.1 and Kir5.1.
The Kir4 subfamily has been classified as weak rectifiers with intermediate conductance.
Kir4.1 is mainly expressed in brain, specifically in glia cells, but also in retina, ear and kidney.1,2
It has been proposed that Kir4.1 has an essential role in glial K+ buffering, a process that re-uptakes the K+released during neuronal activity into the intracellular interstitial space. Loss of Kir4.1 causes retinal defects and loss of endochoclear potential.3
The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heteromers.
Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis.
Kir4.1 is a member of the Kir4 subfamily that includes one other member: Kir4.2. Kir4.1 can co-assemble with Kir4.2 but also with other Kir channels such as Kir2.1 and Kir5.1.
The Kir4 subfamily has been classified as weak rectifiers with intermediate conductance.
Kir4.1 is mainly expressed in brain, specifically in glia cells, but also in retina, ear and kidney.1,2
It has been proposed that Kir4.1 has an essential role in glial K+ buffering, a process that re-uptakes the K+released during neuronal activity into the intracellular interstitial space. Loss of Kir4.1 causes retinal defects and loss of endochoclear potential.3
制备和贮存
溶解方法
25 μl, 50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
29718
UniProt ID
P49655
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