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产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
Rabbit
免疫原
Peptide (C)EDEVAAKEGNSPGPQ, corresponding to amino acid residues 1943-1956 of rat NaV1.8 (Accession Q63554). Intracellular, C-terminus.
简单描述
A Rabbit Polyclonal Antibody to NaV1.8 (SCN10A) Channel Conjugated to the Fluorescent Dye ATTO-594
商品描述
Anti-NaV1.8 (SCN10A) Antibody (#ASC-016) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunoprecipitation, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize NaV1.8 from rat, human, and mouse samples.
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
形式
Lyophilized
组成成分
抗蛋白抗体
基因
SCN10A
应用
实验应用
IF, IHC
反应种属
H, R
背景
别名
PN3, SNS, Sodium channel protein type 10 subunit alpha
背景
Voltage-gated Na+ channels (Nav) are essential for the generation of action potentials and for cell excitability1. Nav channels are activated in response to depolarization and selectively allow the flow of Na+ ions. To date, nine Nav α subunits have been cloned and named Nav1.1-1.9 2,3. The Nav channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels4,5. Their expression is developmentally regulated and tissue specific.
Two TTX-resistant Nav channels are expressed in dorsal root ganglion (DRG) neurons, Nav1.8 and Nav1.9. The Nav1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons4,6. TTX-resistant channels have been suggested to play an important role in nociceptive transmission.
Recently, the involvement of Nav1.8 in multiple sclerosis (MS) was suggested due to the up-regulation of both, mRNA and protein in Purkinje cells of MS patients and also in animal models6.
Two TTX-resistant Nav channels are expressed in dorsal root ganglion (DRG) neurons, Nav1.8 and Nav1.9. The Nav1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons4,6. TTX-resistant channels have been suggested to play an important role in nociceptive transmission.
Recently, the involvement of Nav1.8 in multiple sclerosis (MS) was suggested due to the up-regulation of both, mRNA and protein in Purkinje cells of MS patients and also in animal models6.
制备和贮存
溶解方法
50 µl double distilled water (DDW).
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
29571
UniProt ID
Q63554
研究资源识别码
AB_2341068.
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