全部商品分类
用小程序，查商品更便捷
产品介绍
产品信息
纯化方式
Affinity purified on immobilized antigen.
宿主
Rabbit
免疫原
Peptide (C)RHRLWEMVGRWDH, corresponding to amino acid residues 365-377 of rat NMDAR2C (Accession Q00961). Extracellular, N-terminus.
简单描述
A Rabbit Polyclonal Antibody to NMDA Receptor 2C (GRIN2C)
商品描述
Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of rat NMDA receptor 2C. Anti-NMDAR2C (GRIN2C) (extracellular) Antibody (#AGC-018) can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize NR2C from human, rat, and mouse samples.
同种型
Rabbit IgG.
纯度
Affinity purified on immobilized antigen.
形式
Lyophilized
组成成分
免疫球蛋白G型抗体
基因
GRIN2C
应用
实验应用
ICC, IF, IHC, WB
反应种属
H, M, R
背景
别名
NMDA receptor 2C, NR2C, GluN2C, Ionotropic glutamate receptor subunit ε3, N-methyl-D-aspartate receptor subunit 2C
背景
The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kainate receptors.
The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.
The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neuronal depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels.
NMDA are generally highly expressed in the central nervous system, particularly in the brain. In addition, NMDAR2C has been also detected in the heart, sketeletal muscle, and pancreas.
Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s disease.
The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.
The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.
The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neuronal depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels.
NMDA are generally highly expressed in the central nervous system, particularly in the brain. In addition, NMDAR2C has been also detected in the heart, sketeletal muscle, and pancreas.
Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s disease.
The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.
制备和贮存
溶解方法
25 μl, 50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
保存方式
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
数据库链接
Entrez-Gene ID
24411
UniProt ID
Q00961
研究资源识别码
AB_10557315.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。