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APC Anti-CD31 antibody [SP164] (C-terminal)
品牌： Abcam
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Protein A/G purified
来源宿主：
Rabbit
产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed : 17580308, PubMed : 19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed : 19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed : 27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed : 17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed : 12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed : 12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed : 18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed : 18672896). Induces susceptibility to atherosclerosis (By similarity).. Isoform Delta15. Does not protect against apoptosis.
宿主
Rabbit
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
简单描述
APC兔单克隆抗体[SP164] to CD31 - C-terminal
商品描述
Rabbit Recombinant Monoclonal CD31 antibody - conjugated to APC.
同种型
IgG
克隆号
SP164
克隆类别
单克隆
纯度
Protein A/G purified
形式
Liquid
研究领域
其他
应用
实验应用
Target Binding Affinity, Antibody Labelling
背景
别名
CD31, Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', PECA1, PECAM1
研究领域
Cardiovascular Blood Platelets Signal Transduction Cytoskeleton / ECM Cell Adhesion Cell Adhesion Molecules Endothelial Cardiovascular Angiogenesis Angiogenic Factors Stem Cells Mesenchymal Stem Cells Surface Molecules Cancer Invasion/microenvironment ECM Cell adhesion Other Cancer Tumor immunology CD markers Cardiovascular Atherosclerosis Vascular Inflammation Leukocyte recruitment Cell adhesion molecules Stem Cells Hematopoietic Progenitors Lymphoid T Lymphocytic Lineage Stem Cells Hematopoietic Progenitors Myeloid Monocytic Lineage Stem Cells Hematopoietic Progenitors Myeloid Neutrophil Lineage Stem Cells Hematopoietic Progenitors Myeloid Thrombocytic Lineage Cardiovascular Cardiovascular Markers Cell Markers Endothelial Cells Cardiovascular Angiogenesis Endothelial Cell Markers
制备和贮存
存储溶液
pH: 7.4Preservative: 0.02% Sodium azideConstituents: 98% PBS, 1% BSA
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. Store In the Dark.
数据库链接
UniProt ID
P16284
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