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产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed : 23391734, PubMed : 9020188). In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed : 28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed : 23391734, PubMed : 26122121, PubMed : 9020188).
宿主
Rabbit
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
简单描述
APC兔单克隆抗体[Y141] to STAT2
商品描述
Rabbit Recombinant Monoclonal STAT2 antibody - conjugated to APC.
同种型
IgG
克隆号
Y141
克隆类别
单克隆
纯度
Protein A purified
形式
Liquid
研究领域
表观遗传学
应用
实验应用
Antibody Labelling, Target Binding Affinity
目标/特异性
This antibody detects both long and short forms of STAT2.
背景
别名
Signal transducer and activator of transcription 2, p113, STAT2
研究领域
Signal Transduction Signaling Pathway Nuclear Signaling STATs Epigenetics and Nuclear Signaling Transcription Other factors Epigenetics and Nuclear Signaling Nuclear Signaling Pathways STATs Microbiology Organism Virus RNA Virus ssRNA positive strand virus SARS Coronavirus
制备和贮存
存储溶液
pH: 7.40Preservative: 0.02% Sodium azideConstituents: 98% PBS, 1% BSA
保存方式
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. Store In the Dark.
数据库链接
UniProt ID
P52630
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