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产品介绍
产品信息
商品描述
Arachidonic acid is an unsaturated fatty acid of cell membrane phospholipids and has been known to serve as a precursor to numerous eicosanoids and prostoglandins as well as other bioactive molecules. Ibuprofin is known to prevent arachadonic acid from being converted into various prostoglandins by acetylating cyclooxygenases. Experiments have shown that Arachidonic acid can cause activation of PKC. Further studies have demonstrated Arachidonic acid to cause release of Ca2+ from isolated cardiac and skeletal sarcoplasmic reticulum vesicles. This compound has demonstrated a capacity to directly activate GTP binding protein in the neutrophil plasma membrane and induce superoxide anion generation from intact neutrophils.
分子量
304.47
纯度
99%
可溶性
Soluble in DMSO (100 mg/ml), DMF (100 mg/ml), 100% ethanol (50 mg/ml), methanol (50 mg/ml), chloroform (50 mg/ml), dichloromethane, hexane, acetonitrile, and ether. Sparingly soluble in basic aqueous buffers (1.7 mg/ml)
外观
无色至淡黄色液体
IC50
THP-1: IC50 = 4.7 nM (human); mPGES1: IC50 = 300 nM; LTB4 production: IC50 = 940 nM (human)
应用
实验应用
A protein kinase C activator
背景
别名
5,8,11,14-二十碳四烯酸
分子式
C20H32O2
CAS号
506-32-1
EC号码
208-033-4
沸点
169-171° C (lit.) at 0.15 mmHg
MDL
MFCD00004417
PK值
pKa: 4.75
密度
~0.9 g/mL (Predicted)
折射率
n20D 1.49 (lit.)
制备和贮存
保存方式
-20° C
参考图片
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