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ARH, CT (Low Density Lipoprotein Receptor Adapter Protein 1, Autosomal Recessive Hypercholesterolemia Protein, LDLRAP1)


品牌: MyBioSource








反应种属:
Human
实验应用:
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by Protein A affinity chromatography.

抗原名称
arylphorin

免疫原
Synthetic peptide selected from the C-terminal region of human LDLRAP1 (KLH).

商品描述
LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

形式
Supplied as a liquid in PBS, 0.09% sodium azide.

产品类型
Polyclonal

应用
实验应用
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

反应种属
Human

背景
别名
Anti -ARH, CT (Low Density Lipoprotein Receptor Adapter Protein 1, Autosomal Recessive Hypercholesterolemia Protein, LDLRAP1)

制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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