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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly561 of human ARHGAP29 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
同种型
Rabbit IgG
分子量
142
应用
目标/特异性
Specificity/Sensitivity
ARHGAP29 (F6O5B) Rabbit mAb recognizes endogenous levels of total ARHGAP29 protein. By western blot, this antibody detects a band of unknown origin at approximately 10 kDa.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Rho GTPase-activating protein 29 (ARHGAP29), also known as PARG1, suppresses Rho family GTPase signaling by promoting GTP hydrolysis and the inactive (GDP-bound) state. Transcription of ARHGAP29 is positively regulated by Yes-associated protein (YAP), destabilizing the actin cytoskeleton and promoting cell migration (1). Upregulated expression of ARHGAP29 is associated with invasion and proliferation in human prostate, breast, and kidney cancer cells, and may serve as a prognostic indicator in several human cancers (1-4). Mutation of the ARHGAP29 gene is associated with nonsyndromic cleft lip and/or palate (NSCL/P) in humans (5,6).
1.Qiao, Y. et al. (2017) Cell Rep 19, 1495-1502.
2.Shimizu, K. et al. (2020) Oncol Rep 44, 2735-2745.
3.Kolb, K. et al. (2020) Cells 9, 2616. doi: 10.3390/cells9122616.
4.Miyazaki, J. et al. (2017) Transl Oncol 10, 142-152.
5.Leslie, E.J. et al. (2012) Birth Defects Res A Clin Mol Teratol 94, 934-42.
6.Liu, H. et al. (2017) Birth Defects Res 109, 27-37.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
9411
UniProt ID
Q52LW3
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