细胞铁死亡(Ferroptosis)相关产品线热卖中-优宁维(univ)官网
 >  资讯
资讯

细胞铁死亡(Ferroptosis)相关产品线热卖中

浏览次数:686

分享:


细胞铁死亡(Ferroptosis)是一种铁依赖性脂质过氧化物积累所引发的新型细胞死亡方式。铁离子极大地加速了脂肪酸的过氧化反应,脂质过氧化物在铁的调控下累计,这些脂质reactive oxygen species(ROS)超出细胞抗氧化系统的承受能力,氧化过程损伤胞内蛋白、核酸和脂质,导致细胞死亡。

常规细胞凋亡或坏死常常伴随着细胞器肿大、染色质聚合、细胞膜完整性下降等特征,而细胞铁死亡在细胞形态上引起的改变甚微,往往只伴随细胞体积略微减小、线粒体膜密度增加等。



引发铁死亡通路(ferroptotic pathway)关键因素:

  ★ 贮藏在磷脂膜中的多不饱和长链脂肪酸(PUFAs)
  ★ 可氧化还原的铁离子
  ★ 有缺陷的脂质过氧化修复系统

在癌症研究领域中,Ferroptosis suppressor protein 1(FSP1) Glutathione peroxidase 4(GPX4)已成为重要研究靶点。FSP1和GPX4作为细胞铁死亡通路的负调节因子,阻碍细胞铁死亡。其FSP1和GPX4抑制剂则能有效激活癌细胞的铁死亡,该类抑制剂的药物筛选也已成为研究新型抗癌治疗方法的热点项目。


Ferroptosis分子机制与信号通路图:


优宁维为您提供全面、优质、方便快捷的Ferroptosis相关产品线!!



其中优宁维代理的Cayman公司最新上市的FSP1 Fluorescent Inhibitor Screening Assay kit(Item No.701900)和GPX4 Inhibitor Screening Assay Kit(Item No.701880)。该分析试剂盒是市场上第一款能提供方便快捷FSP1和GPX4新型抑制剂药物筛选的产品,为发现铁死亡相关新型抗癌药物提供便利。

Identify Novel Inducers of Ferroptosis
GPX4 Inhibitor 
Screening Assay Kit
Item No. 701880
- Includes recombinant human GPX4 and positive control GPX4 inhibitor ML-162
- Assay 45 samples in duplicate or 29 samples in triplicate
- Plate-based colorimetric measurement (340nm)
FSP1 Fluorescent Inhibitor
Screening Assay Kit
Item No. 701900
- Includes recombinant human FSP1 and positive control FSP1 inhibitor iFSP1
- Assay 45 samples in duplicate or 29 samples in triplicate
- Plate-based colorimetric measurement (590nm)

除了以上两个首发的试剂盒以外,我们还可提供铁死亡相关产品线:抑制剂与诱导剂,氧化磷脂,检测试剂盒,抗体,探针等。

Ferroptosis产品线部分商品:

抑制剂与诱导剂(Inhibitors&Inducers)

货号

抑制剂与诱导剂(Inhibitors&Inducers)

28966

PKUMDL-LC-101-DO4

11884

Rosiglitazone(maleate)

31002

Pantothenate Kinase Inhibitor

10009644

Sorafenib

氧化磷脂

(Oxidized lipids)

货号

氧化磷脂(Oxidized Phospholipids)

21138

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC

21139

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE

26531

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC

25856

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

检测类商品

(Assay products)

货号

GPX检测(GPX Detection)

703102

Glutathione Peroxidase Assay Kit

26906

GPX4(human,recombinant);selenocysteine incorporation confirmed by MS

10005258

GPX4 Polyclonal Antibody

货号

GSH活性检测(GSH Activity Assays)

703002

Glutathione Assay Kit

600360

Glutathione Cell-Based Detection Kit(Blue Fluorescence)

703202

Glutathione Reductase Assay Kit

货号

FSP1检测(FSP1 Detection)

29611

FSP1 (human, recombinant)

29554

Coumarin-Quinone Conjugate

货号

脂氧合酶&抑制剂筛选(Lipoxygenases & Inhibitor Screening Assay)

60402

5-Lipoxygenase (human, recombinant)

10341

12-Lipoxygenase (platelet-type, mouse recombinant)

10011263

15-Lipoxygenase-2 (human recombinant)

760700

Lipoxygenase Inhibitor Screening Assay Kit

货号

脂质ROS检测试剂盒(Lipid ROS Assay Kits)

501140

DHN-MA EIA Kit

705002

Lipid Hydroperoxide (LPO) Assay Kit

601290

ROS Detection Cell-Based Assay Kit (DHE)

10009055

TBARS Assay Kit

抗体类商品

(Antibodies)

货号

GSH衍生物和抗体(GSH Derivatives and Antibodies)

14953

Glutathione ethyl ester

10007461

L-Glutathione,reduced

10010013

Glutathione S-Transferase Polyclonal Antibody

4393S

FTH1 (D1D4) Rabbit mAb

19689S

Cystathionine γ-Lyase (D1N1D) Rabbit mAb

52455S

GPX4 Antibody

43966S

HO-1 (E3F4S) Rabbit mAb

58135S

LOX (D8F2K) Rabbit mAb

66849S

NCOA4 (E8H8Z) Rabbit mAb

20272S

IRP1 (D6S4J) Rabbit mAb

37135S

IRP2 (D6E6W) Rabbit mAb

12282S

Cox2 (D5H5) XP® Rabbit mAb

12691S

xCT/SLC7A11 (D2M7A) Rabbit mAb

探针

(Probe)

货号

脂质ROS探针(Lipid ROS Probes)

27086

C11 BODIPY 581/591

62237

DPPP

13265

4-hydroxy Nonenal Alkyne

其他化合物产品

(Others)

货号

脂质过氧化物(Lipid Peroxidation End Products)

10004413

4-hydroperoxy 2-Nonenal

32100

4-hydroxy Nonenal

10185

4-oxo-2-Nonenal

10627

4-hydroxy Nonenal Glutathione (trifluoroacetate salt)

32110

4-hydroxy Nonenal Mercapturic Acid

货号

亲脂抗氧化剂(Lipophilic Antioxidants)

89910

BHT

81880

tetrahydro-L-Biopterin (hydrochloride)

11506

Coenzyme Q10

70530

Ebselen

15475

Idebenone

10008377

α-Tocotrienol

10011659

Trolox