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Ascomycin (FK520)
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产品介绍
产品介绍
产品信息
抗原名称
calcineurin phosphatase
商品描述
Ascomycin (FK520), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
分子量
792.01
纯度
＞98%
可溶性
DMSO : 39.6 mg/mL (50 mM)
Ethanol : 39.6 mg/mL (50 mM)
Ethanol : 39.6 mg/mL (50 mM)
外观
白色至类白色结晶性粉末
In vitro(体外研究)
Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. FK520 also accelerate the rate of nerve regeneration, and promotes neurite outgrowth. Ascomycin shows antimalarial effects via inhibition of the chaperone activity of this bifunctional protein.
In vivo(体内研究)
Ascomycin (3.2 mg/kg, i.m.) clearly prolongs skin allograft survival in rats. Ascomycin, at 50 or 100 μM, produces anticonvulsant effect against picrotoxin-induced seizures when infused into the rat hippocampus.
背景
别名
长川霉素；子囊霉素；Immunomycin；FR-900520；FK520
分子式
C43H69NO12
CAS号
104987-12-4；11011-38-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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