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ASIC2A ANTIBODY
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; ACNN1; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
基因别名: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNAC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2
UniProt ID:(Human) Q16515, (Rat) Q62962, (Mouse) Q925H0
Entrez Gene ID:(Human) 40, (Rat) 25364, (Mouse) 11418
参考图片
Expression ofASIC2ainrat spinal cord. Immunohistochemicalstaining of perfusion-fixed frozenrat spinal cordsections with Anti-ASIC2a Antibody &(8)239; (#ASC-012), (1:300), followed bydonkey Anti-rabbit-Cy3.A.ASIC2aimmunoreactivity (red)appeared in neuronal soma (horizontal arrow) in the ventral horn of the spinal cord.B. Pre-incubation of the Antibody with ASIC2aBlocking Peptide (BLP-SC012), suppressed staining. Cell nuclei are stained with DAPI (blue).
Western blot analysisof rat brain membranes: - 1. Anti-ASIC2a Antibody (#ASC-012), (1:200). 2. Anti-ASIC2a Antibody , preincubated with ASIC2a Blocking Peptide (#BLP-SC012).