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ASIC3 ANTIBODY
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acid sensing ion channel 3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; ASIC3; Dorsal root ASIC; DRASIC; hASIC3; proton gated cation channel DRASIC
基因别名: Accn3; Asic3; AW742291; DRASIC; SLNAC1; TNAC1
UniProt ID:(Mouse) Q6X1Y6, (Rat) O35240
Entrez Gene ID:(Mouse) 171209, (Rat) 286920
参考图片
Expression of ASIC3 in mouse dorsal raphe nucleus - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections using Guinea pig Anti-ASIC3 Antibody (#ASC-018-GP), (1:200), followed by goat- Anti-guinea pig-AlexaFluor-488 secondary Antibody . ASIC3 staining (green) appears in the soma of dorsal raphe nucleus (DRN) neurons (arrows). Nuclei are stained with DAPI (blue).
Western blot analysis of rat brain membranes (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4): - 1,2.Guinea pig Anti-ASIC3 Antibody (#ASC-018-GP), (1:1000).3,4. Guinea pig Anti-ASIC3 Antibody , preincubated with ASIC3 Blocking Peptide (#BLP-SC018).
Western blot analysis of rat dorsal root ganglion (DRG) lysate: - 1. Guinea pig Anti-ASIC3 Antibody (#ASC-018-GP), (1:1000). 2. Guinea pig Anti-ASIC3 Antibody , preincubated with ASIC3 Blocking Peptide (#BLP-SC018).