全部商品分类
Anti-ASIC3 Antibody
品牌： Alomone
下载产品说明书
用小程序，查商品更便捷
收藏
对比
咨询纯度：
Affinity purified on immobilized antigen.
反应种属：
H, M, R
产品介绍
产品介绍
产品信息
宿主
兔
简单描述
A Rabbit Polyclonal Antibody to ASIC3 Channel
商品描述
Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to ASIC3 Channel
纯度
Affinity purified on immobilized antigen.
组成成分
酸敏感离子通道蛋白3抗体;磷酸盐缓冲液;防腐剂(0.05%叠氮化钠溶液)
应用
实验应用
IC, IH, WB
反应种属
H, M, R
背景
背景
ASIC3 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial Na+ channels (DEG/ENaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini.
The functional channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits.
A drop in external pH opens the channel resulting in an inward cation current that is quickly inactivated even in the continuous presence of protons in the medium, although a small residual current may persist.
Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Finally, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid.
Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.
The functional channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits.
A drop in external pH opens the channel resulting in an inward cation current that is quickly inactivated even in the continuous presence of protons in the medium, although a small residual current may persist.
Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Finally, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid.
Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。