ASP 2535 (10 mg)

9800113

Potent and selective GlyT1 inhibitor

382.42

4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

Potent and selective GlyT1 inhibitor (IC₅₀ = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 100 mM in ethanol

CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23

C₂₂H₁₈N₆O

374886-51-8