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产品介绍
产品介绍
产品信息
商品描述
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity.
分子量
407.37
纯度
98%
可溶性
DMSO : ≥ 250 mg/mL (613.69 mM)
In vitro(体外研究)
ASP5878 shows potent antiproliferative activity in most human HCC cell lines.ASP5878 inhibits FGFR4 phosphorylation in a concentration-dependent manner. ASP5878 treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.Cell Viability AssayCell Line:Human HCC cell lines.Concentration:0-1000 nM.Incubation Time:5 days.Result:HuH-7, Hep3B2.1-7, and JHH-7 cell lines exhibited potent sensitivity to ASP5878, with IC50 values of 27, 8.5, and 21 nmol/L, respectively. The growth inhibition rate of HLF was 64% and those of other ASP5878-sensitive cell lines were higher than 95% at 1000 nM.
In vivo(体内研究)
ASP5878 shows potent antiproliferative activity in most human HCC cell lines.ASP5878 inhibits FGFR4 phosphorylation in a concentration-dependent manner. ASP5878 treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation.Cell Viability AssayCell Line:Human HCC cell lines.Concentration:0-1000 nM.Incubation Time:5 days.Result:HuH-7, Hep3B2.1-7, and JHH-7 cell lines exhibited potent sensitivity to ASP5878, with IC50 values of 27, 8.5, and 21 nmol/L, respectively. The growth inhibition rate of HLF was 64% and those of other ASP5878-sensitive cell lines were higher than 95% at 1000 nM.
背景
分子式
C18H19F2N5O4
CAS号
1453208-66-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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