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产品介绍
产品介绍
产品信息
商品描述
ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.
分子量
263.26
纯度
98%
可溶性
DMSO :11 mg/mL (41.78 mM)
In vivo(体内研究)
ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model.?ASP7663 activated human, rat, and mouse TRPA1 and released 5-HT from QGP-1 cells, and oral but not intravenous administration of ASP7663 significantly improved the loperamide-induced delay in colonic transit in mice.?While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats[1].
背景
分子式
C14H14FNO3
CAS号
1190217-35-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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