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Rabbit Polyclonal ATF2 [p Thr52] Antibody
品牌： Novus
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对比
咨询分子量：
74 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
纯度：
Antigen Affinity-purified
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
宿主
Rabbit
免疫原
Synthetic phospho-peptide corresponding to amino acid residues surrounding THr52 conjugated to KLH. Accession # P15336
简单描述
Novus Biologicals Rabbit ATF2 [p Thr52] Antibody - Azide Free (NBP2-29528) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
同种型
IgG
分子量
74 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
克隆类别
Polyclonal
纯度
Antigen Affinity-purified
防腐剂
No Preservative
基因
ATF2
应用
实验应用
WB
反应种属
Hu, Mu, Pm;Non-human primate. The antibody has been directly tested for reactivity in Western blots with UACC903 melanoma cells.
目标/特异性
Specific for endogenous levels of the ~72 kDa ATF2 protein phosphorylated at Thr52. Immunolabeling of the ATF2 band is reduced by treatment of the cells with the PKC catalytic inhibitor Go6850.
稀释度
Western Blot 1:250
背景
别名
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
背景
The transcription factor ATF2 is a member of the ATF/CREB family of leucine zipper proteins. In response to stress stimuli, it activates a variety of gene targets that are involved in oncogenesis, and has been correlated with maintenance of a cancer cell phenotype (Vlahopoulos et al., 2008). Inhibiting ATF2 impedes melanoma development and elicits tumor suppressor function (Bhoumik et al., 2008). To act as a tumor suppressor, ATF2 must localize at the mitochondria, and phosphorylation at Thr52 by PKC-epsilon regulates this translocation (Lau et al., 2012).
制备和贮存
存储溶液
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
保存方式
Store at -20C. Avoid freeze-thaw cycles.
数据库链接
UniProt ID
P15336()
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