Axin1 (C76H11) Rabbit mAb

Axin1 (Axis inhibition protein 1) and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin (1,2). Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling (3,4). In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase (JNK/SAPK) (5). Axin2 (also known as Conductin or Axil) can functionally substitute for Axin1 in mice (6). Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop (7-9). 1.Luo, W. and Lin, S.C. Neurosignals 13, 99-113. 2.Salahshor, S. and Woodgett, J.R. (2005) J. Clin. Pathol. 58, 225-236. 3.Zeng, X. et al. (2005) Nature 438, 873-877. 4.Davidson, G. et al. (2005) Nature 438, 867-872. 5.Zhang, Y. et al. (1999) J. Biol. Chem. 274, 35247-35254. 6.Chia, I.V. and Costantini, F. (2005) Mol. Cell Biol. 25, 4371-4376. 7.Jho, E.H. et al. (2002) Mol. Cell Biol. 22, 1172-1183. 8.Lustig, B. et al. (2002) Mol. Cell Biol. 22, 1184-1193. 9.Leung, J.Y. et al. (2002) J. Biol. Chem. 277, 21657-21665.