AZ 191 (10 mg)

72716071

Potent DYRK1B inhibitor

429.52

N-[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine

Potent DYRK1B inhibitor (IC₅₀ values are 17, 88 and 1890 nM for DYRK1B, DYRK1A and DYRK2 respectively). Inhibits DYRK1B-induced G_i phase cell cycle arrest in Panc-1 cells in vitro.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 20 mM in ethanol

CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12

C₂₄H₂₇N₇O

1594092-37-1