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AZ191
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产品介绍
产品介绍
产品信息
抗原名称
DYRK1B ,DYRK1A
商品描述
AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.
分子量
429.52
纯度
>98%
可溶性
DMSO 86 mg/mL (200.22 mM)
Ethanol 1 mg/mL (2.32 mM)
Ethanol 1 mg/mL (2.32 mM)
外观
Powder
In vitro(体外研究)
AZ191 selectively inhibits DYRK1B serine/threonine kinase activity with no effect on tyrosine kinase autophosphorylation. In HEK-293 cells, AZ191 also displays much greater potency for DYRK1B over DYRK1A, inhibiting CCND1 phosphorylation. In HD1B cells, AZ191 strongly inhibits the levels of the cell-cycle regulators, p21Cip1 and p27Kip1, and increases cell-cycle progression.
背景
别名
AZ-191,AZ 191
分子式
C24H27N7O
CAS号
1594092-37-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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