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产品介绍
产品介绍
产品信息
抗原名称
ATM:0.31 μM (in cell), ATM:6.2 nM
商品描述
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.
分子量
328.37
纯度
98%
可溶性
DMSO :150 mg/mL
In vitro(体外研究)
AZ32 is an enhanced blood-brain barrier (BBB)-penetrating ATM inhibitor. AZ32 blocks the DNA damage response and radiosensitized GBM cells in vitro[1].
In vivo(体内研究)
AZ32 has enhanced BBB penetration that is highly efficient in vivo as radiosensitizer in syngeneic and human, orthotopic mouse glioma model compared with AZ31. AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse. Following a single oral dose of AZ32 (200 mg/kg) in mice, the free-brain concentrations of AZ32 are in excess of the cellular IC50 for approximately 22 hours[1].
背景
分子式
C20H16N4O
CAS号
2288709-96-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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