AZD 9272 (10 mg)

9838729

Potent and selective mGlu₅ antagonist; brain penetrant

284.22

3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

Potent and selective mGlu₅ antagonist (IC₅₀ values are 2.6 and 7.6 nM for rat and human receptors, respectively). Exhibits >3900-fold selectivity for mGlu₅ over other mGlu receptors. Also selective over a panel of other targets. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.

≥98% (HPLC)

Soluble to 50 mM in DMSO

FC1=CC=C(C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2)N=C1

C₁₄H₆F₂N₄O

327056-26-8