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产品介绍
产品介绍
产品信息
抗原名称
L858R/T790M EGFR ,Exon 19 deletion EGFR ,WT EGFR
商品描述
AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).
分子量
499.61
纯度
>98%
可溶性
DMSO ：99 mg/mL warmed (198.15 mM)
Ethanol ：43 mg/mL warmed (86.06 mM)
Ethanol ：43 mg/mL warmed (86.06 mM)
外观
Powder
In vitro(体外研究)
AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro.
In vivo(体内研究)
AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo.
背景
别名
EGFR inhibitor; AZD9291; AZD 9291;Tagrisso;Osimertinib; Mereletinib
分子式
C28H33N7O2
CAS号
1421373-65-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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