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BAY11-7085
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产品介绍
产品介绍
产品信息
抗原名称
IκBα phosphorylation
商品描述
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.
分子量
249.33
纯度
＞98%
可溶性
DMSO : 24.9 mg/mL (100 mM)
Ethanol : 24.9 mg/mL (100 mM)
Ethanol : 24.9 mg/mL (100 mM)
外观
white solid
In vitro(体外研究)
BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells.
In vivo(体内研究)
BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells.
背景
分子式
C13H15NO2S
CAS号
196309-76-9
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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