Bcr-abl Inhibitor II

Bcr-abl Inhibitor II is a cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of c-Abl and c-Src (SRC kinases) (Ki = 44 and 354 nM, respectively). Bcr-abl Inhibitor II effectively inhibits cellular Bcr-abl Tyr245 phosphorylation and the clonogenic activity of Bcr-abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571. 参考文献 Radi, M., et al. 2008. Bioorg. Med. Chem. Lett. 18, 1207.

363.40

Bcr-abl Inhibitor II is an inhibitor of c-Abl and SRC kinases

4-fluoro-N-{5-[(4-fluorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}benzamide

C1=CC(=CC=C1CSC2=NN=C(S2)NC(=O)C3=CC=C(C=C3)F)F

C16H11F2N3OS2

607702-99-8