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产品介绍
产品介绍
产品信息
抗原名称
Arginase II,rat Arginase I
商品描述
BEC hydrochloride is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
分子量
229.49
纯度
99%
可溶性
DMSO ：45 mg/mL (196.08 mM)
Water ：45 mg/mL (196.08 mM)
Ethanol ：45 mg/mL (196.08 mM)
Water ：45 mg/mL (196.08 mM)
Ethanol ：45 mg/mL (196.08 mM)
In vitro(体外研究)
BEC causes significant enhancement of NO-dependent smooth muscle relaxation. In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK.
In vivo(体内研究)
In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure.
背景
分子式
C5H12BNO4S.ClH
CAS号
222638-67-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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