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Phospho-beta-Catenin (Ser33/37/Thr41) Antibody
品牌： CST
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对比
咨询分子量：
92
反应种属：
Human,Mouse,Rat,Monkey,
产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
beta-Catenin
来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser33, Ser37 and Thr41 of human β-catenin. Antibodies are purified by protein A and peptide affinity chromatography.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
分子量
92
内毒素水平
鸡 , 非洲爪蟾蜍, 斑马鱼 , 牛 , 犬 , 猪
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
应用
反应种属
Human,Mouse,Rat,Monkey,
预测反应种属
Chicken,Xenopus,Zebrafish,Bovine,Dog,Pig,
目标/特异性
Specificity/Sensitivity
Phospho-β-Catenin (Ser33/37/Thr41) Antibody detects endogenous levels of β-catenin only when phosphorylated at serines 33, 37 or threonine 41. It does not recognize beta-catenin phosphorylated at other sites.
Species Reactivity:
Human, Mouse, Rat, Monkey
敏感性
Endogenous
背景
背景
β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8).
1.Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-3305.
2.Wodarz, A. and Nusse, R. (1998) Annu Rev Cell Dev Biol 14, 59-88.
3.Polakis, P. (1999) Curr Opin Genet Dev 9, 15-21.
4.Amit, S. et al. (2002) Genes Dev 16, 1066-76.
5.Liu, C. et al. (2002) Cell 108, 837-47.
6.Yanagawa, S. et al. (2002) EMBO J 21, 1733-42.
7.Yost, C. et al. (1996) Genes Dev 10, 1443-54.
8.Morin, P.J. et al. (1997) Science 275, 1787-90.
研究领域
癌症,发育生物学与干细胞研究,纤维化,神经科学,
翻译后修饰
phosphate
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
1499
UniProt ID
P35222
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