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产品介绍
产品介绍
产品信息
抗原名称
PDE4B inhibitor:7.2 nM
商品描述
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD) [1] [2] .
分子量
448.97
纯度
98%
可溶性
DMSO:4.49 mg/mL (10 mM)
In vitro(体外研究)
BI 1015550 inhibited Lipopolysaccharides-induced TNF-α release and Phytohemagglutinin P-induced IL-2 release in human PBMCs with IC50 values of 35 nM and 9 nM, respectively.[2
BI 1015550 inhibited the release of TNF-α in rat whole blood with an IC50 value of 91 nM.[2]
In vivo(体内研究)
BI 1015550 (Example 2) (0, 0.3, 1.0 and 3.0 mg/kg ; oral ; single dose) at 1.0 mg/kg weakened intestinal transit in rats, but did not significantly affect body weight.[1]
BI 1015550 prevented inflammation in rat lung tissue with an ED50 value of 0.1 mg/kg.[1]
BI 1015550 (0.01, 0.1 and 1.0 mg/kg ; oral ; single dose) reduced Lipopolysaccharides-induced TNF-α release in mouse plasma in a dose-dependent manner.[2]
BI 1015550 (0.1, 0.3 and 1.0 mg/kg ; oral ; single dose) inhibited lipopolysaccharide-induced neutrophil entry into the bronchoalveolar lavage fluid of male Suncus Murinus and Wistar rats.[2]
BI 1015550 (2.5 mg/kg and 12.5 mg/kg ; oral ; twice a day for 6 days) was effective in ameliorating the damage caused by bleomycin in mice.[2]
背景
分子式
C20H25ClN6O2S
CAS号
1423719-30-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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