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产品介绍
产品介绍
产品信息
抗原名称
KRAS G12C:450 nM, KRAS G12C:750 nM (kd)
商品描述
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
分子量
516.59
纯度
98%
可溶性
DMSO:55 mg/mL (106.47 mM)
In vitro(体外研究)
BI-2852 (Compound 1; 10 nM-10 μM; 2 hours) shows a dose-dependent pERK modulation and antiproliferative effect at EC50s of 6.7 μM and 5.8 μM in low serum and soft agar conditions in NCI-H358 cells.
背景
分子式
C31H28N6O2
CAS号
2375482-51-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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