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产品介绍
产品介绍
产品信息
抗原名称
HER2
商品描述
BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.
分子量
521.57
纯度
98%
可溶性
DMSO : 80 mg/mL (153.38 mM)
外观
Light yellow to yellow Solid
In vitro(体外研究)
BI-4142 shows inhibition with IC50 values of 10 nM, 18 nM, 270 nM and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT and Ba/F3 EGFRWT, respectively.
In vivo(体内研究)
BI-4142 (0-100 mg/kg; p.o.; twice per day for 40 days) inhibits tumor growth and inhibits oncogenic signaling.
背景
分子式
C28H27N9O2
CAS号
2682003-36-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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