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产品介绍
产品介绍
产品信息
抗原名称
Aurora A (Human),Aurora B (Xenopus laevis),Aurora C (Human),MEK1,MEK2
商品描述
BI-847325 is an orally bioavailable, and selective dual <b>MEK/Aurora kinase</b> inhibitor with <b>IC50</b> of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
分子量
464.56
纯度
98%
可溶性
DMSO : 18 mg/mL (38.7 mM)
Ethanol : 1 mg/mL (2.15 mM)
Ethanol : 1 mg/mL (2.15 mM)
外观
Powder
In vitro(体外研究)
BI-847325 shows growth-inhibitory effects on BRAF-mutant and vemurafenib-resistant melanoma cells with IC50 ranging from 0.3 nM to 2 μM, and prevents colony formation in six BRAF-mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression.
In vivo(体内研究)
In mice bearing 1205Lu and 1205LuR xenografts, BI-847325 (75 mg/kg, p.o.) causes significant tumor suppression without significant alteration in the body weights.
背景
别名
BI 847325；BI847325
分子式
C29H28N4O2
CAS号
1207293-36-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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