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产品介绍
产品介绍
产品信息
抗原名称
BTK:0.3 nM (Kd), BTK:1 nM (IC50)
商品描述
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.
分子量
435.52
纯度
98%
可溶性
DMSO:30mg/ml(68.88mM)
In vitro(体外研究)
BIIB068 inhibits B cell, neutrophil and monocyte activation in vitro, but not T cell responses.
In vivo(体内研究)
BIIB068 demonstrated good PK/PD correlation with in vivo EC50 = 0.16 μM based on antibody esponse, similar to in vivo WB pBTK potency in mice. BIIB068 exhibited no adverse effects in the single dose CNS and respiratory studies in rats nor in a single dose cardiovascular study in monkeys. BIIB068 was well tolerated and effective at inhibiting BTK phosphorylation in healthy subjects.
背景
分子式
C23H29N7O2
CAS号
1798787-27-5
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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