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产品信息
商品描述
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
分子量
480.43
纯度
97%
可溶性
H2O:Insoluble,DMSO:12.01 mg/ml (25 mM)
In vitro(体外研究)
Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase.[5]
AG1717 (2 μM) inhibits the binding of integrase to substrate DNA.[5]
In vivo(体内研究)
Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function.[6]
Bis-T-23 (i.p. ; 20, 40 mg/kg) improves proteinuria by altering actin kinetics.[6]
Bis-T-23 (i.p. ; 20, 40 mg/kg) ameliorates or prevents proteinuria and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6]
背景
分子式
C23H20N4O8
CAS号
171674-76-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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